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Literature summary for 3.1.4.17 extracted from

  • Day, J.P.; Dow, J.A.T.; Houslay, M.D.; Davies, S.A.
    Cyclic nucleotide phosphodiesterases in Drosophila melanogaster (2005), Biochem. J., 388, 333-342.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

Cloned(Commentary)

Cloned (Comment) Organism
expression in Drosophila S2 cells, PDE1 Drosophila melanogaster
expression in Drosophila S2 cells, PDE11 Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
sildenafil IC50: IC50: 0.00012 mM, PDE11; IC50: IC50: 0.0013 mM, PDE1 Drosophila melanogaster
zaprinast IC50: 0.0016 mM, PDE11; IC50: 0.071 mM, PDE1 Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
 3',5'-cGMP PDE11 Drosophila melanogaster
0.0153
-
 3',5'-cGMP PDE1 Drosophila melanogaster
0.0185
-
 3',5'-cAMP PDE11 Drosophila melanogaster
0.0205
-
 3',5'-cAMP PDE1 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE1 Drosophila melanogaster 5'-AMP
-
 ?
3',5'-cAMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE11 Drosophila melanogaster 5'-AMP
-
 ?
3',5'-cGMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE1 Drosophila melanogaster 5'-GMP
-
 ?
3',5'-cGMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE11 Drosophila melanogaster 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
dual-specificity PDE
-
 Drosophila melanogaster
PDE1
-
 Drosophila melanogaster
PDE11
-
 Drosophila melanogaster

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00012
-
 IC50: 0.00012 mM, PDE11 Drosophila melanogaster sildenafil
0.0013
-
 IC50: 0.0013 mM, PDE1 Drosophila melanogaster sildenafil
0.0016
-
 IC50: 0.0016 mM, PDE11 Drosophila melanogaster zaprinast
0.071
-
 IC50: 0.071 mM, PDE1 Drosophila melanogaster zaprinast