Cloned (Comment) | Organism |
---|---|
expression in Drosophila S2 cells, PDE1 | Drosophila melanogaster |
expression in Drosophila S2 cells, PDE11 | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | IC50: IC50: 0.00012 mM, PDE11; IC50: IC50: 0.0013 mM, PDE1 | Drosophila melanogaster | |
zaprinast | IC50: 0.0016 mM, PDE11; IC50: 0.071 mM, PDE1 | Drosophila melanogaster |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
3',5'-cGMP | PDE11 | Drosophila melanogaster | |
0.0153 | - |
3',5'-cGMP | PDE1 | Drosophila melanogaster | |
0.0185 | - |
3',5'-cAMP | PDE11 | Drosophila melanogaster | |
0.0205 | - |
3',5'-cAMP | PDE1 | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | specific for 3',5'-cGMP and 3',5'-cAMP, PDE1 | Drosophila melanogaster | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | specific for 3',5'-cGMP and 3',5'-cAMP, PDE11 | Drosophila melanogaster | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | specific for 3',5'-cGMP and 3',5'-cAMP, PDE1 | Drosophila melanogaster | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | specific for 3',5'-cGMP and 3',5'-cAMP, PDE11 | Drosophila melanogaster | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dual-specificity PDE | - |
Drosophila melanogaster |
PDE1 | - |
Drosophila melanogaster |
PDE11 | - |
Drosophila melanogaster |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00012 | - |
IC50: 0.00012 mM, PDE11 | Drosophila melanogaster | sildenafil | |
0.0013 | - |
IC50: 0.0013 mM, PDE1 | Drosophila melanogaster | sildenafil | |
0.0016 | - |
IC50: 0.0016 mM, PDE11 | Drosophila melanogaster | zaprinast | |
0.071 | - |
IC50: 0.071 mM, PDE1 | Drosophila melanogaster | zaprinast |