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Literature summary for 3.1.4.17 extracted from

  • O'Grady, S.M.; Jiang, X.; Maniak, P.J.; Birmachu, W.; Scribner, L.R.; Bulbulian, B.; Gullikson, G.W.
    Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells (2002), J. Membr. Biol., 185, 137-144.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2R,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol IC50: 0.0043 mM, PDE2 Homo sapiens
(2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one IC50: 0.000006 mM, PDE3; IC50: 0.0012 mM, PDE2; IC50: 0.015 mM, PDE1 Homo sapiens
2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride IC50: 0.005 mM, PDE1; IC50: 0.037 mM, PDE2 Homo sapiens
Cilostamide IC50: 0.00013 mM, PDE3; IC50: 0.048 mM, PDE2; IC50: 0.221 mM, PDE1 Homo sapiens
quinazolinamine IC50: 0.01 mM, PDE3; IC50: 0.23 mM, PDE1; IC50: 0.241 mM, PDE2 Homo sapiens
RP-73401 IC50: 0.05 mM, PDE3; IC50: 0.067 mM, PDE2; IC50: 0.13 mM, PDE1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-84 cell PDE1 Homo sapiens
-
T-84 cell PDE2 Homo sapiens
-
T-84 cell PDE3 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDE1
-
 Homo sapiens
PDE2
-
 Homo sapiens
PDE3
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000006
-
 IC50: 0.000006 mM, PDE3 Homo sapiens (2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
0.00013
-
 IC50: 0.00013 mM, PDE3 Homo sapiens Cilostamide
0.0012
-
 IC50: 0.0012 mM, PDE2 Homo sapiens (2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
0.0043
-
 IC50: 0.0043 mM, PDE2 Homo sapiens (2R,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
0.005
-
 IC50: 0.005 mM, PDE1 Homo sapiens 2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride
0.01
-
 IC50: 0.01 mM, PDE3 Homo sapiens quinazolinamine
0.015
-
 IC50: 0.015 mM, PDE1 Homo sapiens (2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
0.037
-
 IC50: 0.037 mM, PDE2 Homo sapiens 2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride
0.048
-
 IC50: 0.048 mM, PDE2 Homo sapiens Cilostamide
0.05
-
 IC50: 0.05 mM, PDE3 Homo sapiens RP-73401
0.067
-
 IC50: 0.067 mM, PDE2 Homo sapiens RP-73401
0.13
-
 IC50: 0.13 mM, PDE1 Homo sapiens RP-73401
0.221
-
 IC50: 0.221 mM, PDE1 Homo sapiens Cilostamide
0.23
-
 IC50: 0.23 mM, PDE1 Homo sapiens quinazolinamine
0.241
-
 IC50: 0.241 mM, PDE2 Homo sapiens quinazolinamine