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Literature summary for 3.1.4.12 extracted from

  • Collenburg, L.; Beyersdorf, N.; Wiese, T.; Arenz, C.; Saied, E.M.; Becker-Flegler, K.A.; Schneider-Schaulies, S.; Avota, E.
    The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration (2017), Front. Immunol., 8, 1007.
    View publication on PubMed
Search for more literature for 3.1.4.12

Inhibitors

Inhibitors Comment Organism Structure
ES048 when tested in splenocyte extracts, ES048 specifically inhibits enzyme activity up to a concentration of 0.002 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
lymph node
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O
-
 Homo sapiens 6-hexadecanoylamino-4-methylumbelliferone + phosphorylcholine
-
 ?

Synonyms

Synonyms Comment Organism
neutral sphingomyelinase
-
 Homo sapiens
NSM
-
 Homo sapiens
SMase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme ablation reduces cell polarity Homo sapiens
physiological function the enzyme activity is important in T cell recruitment and directional migration. The enzyme is highly important in directional T cell motility in response to SDF1-alpha Homo sapiens