Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GW4869 | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
neutral sphingomyelinase 2 | - |
Mus musculus |
nSMase2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | addition of tumor necrosis factor-alpha, interleukin-1beta, interferon-gamma, and lipopolysaccharide to C2C12 cells elicits significant increases in enzyme activity levels | up |
General Information | Comment | Organism |
---|---|---|
physiological function | neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation. Enzyme activation is required for the development of infection-induced diaphragm calpain activation and muscle weakness | Mus musculus |