Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phorbol 12-myristate 13-acetate does not increase in vitro N-SMase activity protein kinase C-delta does not regulate tumor necrosis factor-induced N-SMase activity | Homo sapiens | |
tumor necrosis factor | induces N-SMase activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
plasma membrane | phorbol 12-myristate 13-acetate induces nSMase2 translocation to the plasma membrane in a time- and dose-dependent manner, rottlerin inhibits nSMase2 translocation in response to tumor necrosis factor and phorbol 12-myristate 13-acetate | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
lung epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
choline-methyl-sphingomyelin + H2O | - |
Homo sapiens | ? | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-SMase | - |
Homo sapiens |
neutral sphingomyelinase | - |
Homo sapiens |
neutral sphingomyelinase-2 | - |
Homo sapiens |
nSMase2 | - |
Homo sapiens |