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Literature summary for 3.1.4.12 extracted from
- Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells (2007), Antioxid. Redox Signal., 9, 817-828.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Fas ligand | activates sphingomyelinases, expecially acid SMase | Bos taurus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | acid sphingomyelinase, ASM, downregulation by specific siRNA leads to reduced FasL-induced lipid raft clustering and Fas aggregation on endothelial cell membrane | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell membrane | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | acid sphingomyelinase redox amplification in mediating the formation of lipid raft redox signaling platforms in coronary arterial endothelial cells, overview | ? | - |
? |  |
| sphingomyelin + H2O | Bos taurus | acid sphingomyelinase is involved in ceramide signaling, which is important in the lipid raft clustering and formation of redox signaling platform in cell membranes, overview, reactive oxygen species derived from ASM/ceramide triggered lipid raft redox signaling platforms can feedback regulate the ASM activity, FasL-induced O2- may be involved in this regulatory mechanism, overview | N-acylsphingosine + choline phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | coronary arterial endothelial cells | Bos taurus | - |
| heart | coronary arterial endothelial cells | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | acid sphingomyelinase redox amplification in mediating the formation of lipid raft redox signaling platforms in coronary arterial endothelial cells, overview | Bos taurus | ? | - |
? | |
| N-methyl-sphingomyelin + H2O | - |
Bos taurus | N-methyl-N-acylsphingosine + choline phosphate | - |
? | |
| sphingomyelin + H2O | - |
Bos taurus | N-acylsphingosine + choline phosphate | - |
? | |
| sphingomyelin + H2O | acid sphingomyelinase is involved in ceramide signaling, which is important in the lipid raft clustering and formation of redox signaling platform in cell membranes, overview, reactive oxygen species derived from ASM/ceramide triggered lipid raft redox signaling platforms can feedback regulate the ASM activity, FasL-induced O2- may be involved in this regulatory mechanism, overview | Bos taurus | N-acylsphingosine + choline phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid SMase | - |
Bos taurus |
| acid sphingomyelinase | - |
Bos taurus |
| ASM | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
ASM assay at | Bos taurus |
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Release 2023.1 (January 2023)
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