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Literature summary for 3.1.4.12 extracted from
- In vitro effects of fat, FA, and cholesterol on sphingomyelin hydrolysis induced by rat intestinal alkaline sphingomyelinase (2002), Lipids, 37, 469-474.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1-oleoyl-rac-glycerol | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus |  |
| 1-stearoyl-rac-glycerol | approx. 10% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
| arachidonic acid | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus | |
| linoleic acid | approx. 20% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
| linolenic acid | approx. 30% stimulation at 0.8-1.6 mM, inhibition above | Rattus norvegicus | |
| oleic acid | approx. 40% stimulation at 0.8 mM, inhibition above | Rattus norvegicus | |
| stearic acid | approx. 20% stimulation at 0.4-0.8 mM, inhibition above | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,2-dioleoyl-sn-glycerol | approx. 40% inhibition at 3.2 mM | Rattus norvegicus | |
| 1,2-distearoyl-rac-glycerol | approx. 30% inhibition at 3.2 mM | Rattus norvegicus | |
| 1-oleoyl-rac-glycerol | slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM | Rattus norvegicus | |
| 1-stearoyl-rac-glycerol | slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
| arachidonic acid | slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM | Rattus norvegicus | |
| ceramide | strong inhibition in the presence of 0.4 mM linoleic acid | Rattus norvegicus | |
| cholesterol | strong inhibition in the presence of 0.4 mM linoleic acid | Rattus norvegicus | |
| linoleic acid | slight stimulation below 0.8 mM, approx. 45% inhibition at 3.2 mM | Rattus norvegicus | |
| linolenic acid | stimulation below 0.8 mM, approx. 15% inhibition at 3.2 mM | Rattus norvegicus | |
| oleic acid | stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
| stearic acid | slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM | Rattus norvegicus | |
| triolein | approx. 30% inhibition at 3.2 mM | Rattus norvegicus | |
| tristearin | approx. 35% inhibition at 3.2 mM | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | Rattus norvegicus | - |
N-acylsphingosine + choline phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingomyelin + H2O | - |
Rattus norvegicus | N-acylsphingosine + choline phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkaline SMase | - |
Rattus norvegicus |
| alkaline sphingomyelinase | - |
Rattus norvegicus |
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