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Literature summary for 3.1.4.12 extracted from

  • Okazaki, T.; Bielawska, A.; Domae, N.; Bell, R.M.; Hannun, Y.A.
    Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation (1994), J. Biol. Chem., 269, 4070-4077.
    View publication on PubMed
Search for more literature for 3.1.4.12

Activating Compound

Activating Compound Comment Organism Structure
deoxycholate
-
 Homo sapiens
additional information
-
 Homo sapiens
phosphatidic acid
-
 Homo sapiens
phosphatidylinositol
-
 Homo sapiens
phosphatidylserine
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ slight Homo sapiens
Cu2+
-
 Homo sapiens
Fe3+
-
 Homo sapiens
additional information
-
 Homo sapiens
Zn2+
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 1 * 95000 + 1 * 45000, gel filtration Homo sapiens
95000
-
 1 * 95000 + 1 * 45000, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
4475fold Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 different assay conditions, substrates etc. Homo sapiens

Subunits

Subunits Comment Organism
dimer 1 * 95000 + 1 * 45000, gel filtration Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Homo sapiens