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Literature summary for 3.1.4.11 extracted from
- Phospholipase C delta 1 inhibits WNT/beta-catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma (2023), Clin. Epigenetics, 15, 30.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the enzyme (PLCD1) is a promising prognostic biomarker for renal cell carcinoma | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P51178 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| breast | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| esophagus | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| HEK-293 cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| larynx | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lymph node | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| rectum | - |
Homo sapiens | - |
| RHEK-1 cell | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| trachea | - |
Homo sapiens | - |
| uterine cervix | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase C delta 1 | - |
Homo sapiens |
| PLCD1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | PLCD1 is a functional tumor suppressor gene downregulated by promoter CpG methylation in renal cell carcinoma | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| drug target | the enzyme (PLCD1) is a promising treatment target for renal cell carcinoma | Homo sapiens |
| physiological function | the enzyme (PLCD1) is a potent tumor suppressor frequently inactivated by promoter methylation in RCC and exerts its tumor suppressive functions via suppressing WNT/beta-catenin and EGFR-FAK-ERK signaling | Homo sapiens |
| physiological function | the enzyme is involved in calcium homeostasis, energy metabolism, intracellular transport and signal transduction | Homo sapiens |
| physiological function | the enzyme (PLCD1) mediates cellular metabolism and homeostasis, intracellular signal transduction and movement | Homo sapiens |
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