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Literature summary for 3.1.4.11 extracted from

  • Cocco, L.; Follo, M.Y.; Manzoli, L.; Suh, P.G.
    Phosphoinositide-specific phospholipase C in health and disease (2015), J. Lipid Res., 56, 1853-1860 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoforms PI-PLCbeta, PI-PLCepsilon, PI-PLCeta, PI-PLCdelta, PI-PLCgamma, and PI-PLCzeta Homo sapiens 5737
-
nucleus isoforms PI-PLCzeta and PI-PLCbeta1 Homo sapiens 5634
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isoform PI-PLCbeta1 Homo sapiens
-
spermatozoon isoform PI-PLCzeta Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
phosphoinositide-specific phospholipase C
-
 Homo sapiens
PI-PLCbeta1 isoform Homo sapiens
PI-PLCbeta2 isoform Homo sapiens
PI-PLCbeta3 isoform Homo sapiens
PI-PLCdelta1 isoform Homo sapiens
PI-PLCdelta3 isoform Homo sapiens
PI-PLCepsilon isoform Homo sapiens
PI-PLCeta isoform Homo sapiens
PI-PLCgamma isoform Homo sapiens
PI-PLCzeta isoform Homo sapiens

General Information

General Information Comment Organism
malfunction lack of isoform PI-PLCbeta1 is linked to myelodysplastic syndrome progression toward acute myeloid leukemia. Loss of both PI-PLCbeta2 and PI-PLCbeta3 isozymes is associated with an impaired T-cell migration that is caused by an inability to increase the intracellular calcium. Isoform PI-PLCbeta 2 downregulation plays an important role in M1-M2 macrophage differentiation, whereas PI-PLCbeta3 activity is essential for promoting macrophage survival, especially in atherosclerotic plaques. Isoform PI-PLCbeta3 deficiency is also linked to the development of myeloproliferative neoplasm Homo sapiens
physiological function isoform PI-PLCgamma plays a specific key role in cell migration and invasion, therefore contributing to carcinogenesis. Isoform PI-PLCzeta is specifically connected with the molecular activation of oocytes following fertilization. PI-PLCbeta isozymes participate in the differentiation and activation of immune cells that control both the innate and adaptive immune systems. Isoform PI-PLCdelta1 is required for the maintenance of homeostasis in skin and metabolic tissues, while PI-PLCdelta3 specifically regulates microvilli formation in enterocytes and the radial migration of neurons in the cerebral cortex of the developing brain Homo sapiens