Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isoforms PI-PLCbeta, PI-PLCepsilon, PI-PLCeta, PI-PLCdelta, PI-PLCgamma, and PI-PLCzeta | Homo sapiens | 5737 | - |
nucleus | isoforms PI-PLCzeta and PI-PLCbeta1 | Homo sapiens | 5634 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | - |
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | isoform PI-PLCbeta1 | Homo sapiens | - |
spermatozoon | isoform PI-PLCzeta | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphoinositide-specific phospholipase C | - |
Homo sapiens |
PI-PLCbeta1 | isoform | Homo sapiens |
PI-PLCbeta2 | isoform | Homo sapiens |
PI-PLCbeta3 | isoform | Homo sapiens |
PI-PLCdelta1 | isoform | Homo sapiens |
PI-PLCdelta3 | isoform | Homo sapiens |
PI-PLCepsilon | isoform | Homo sapiens |
PI-PLCeta | isoform | Homo sapiens |
PI-PLCgamma | isoform | Homo sapiens |
PI-PLCzeta | isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | lack of isoform PI-PLCbeta1 is linked to myelodysplastic syndrome progression toward acute myeloid leukemia. Loss of both PI-PLCbeta2 and PI-PLCbeta3 isozymes is associated with an impaired T-cell migration that is caused by an inability to increase the intracellular calcium. Isoform PI-PLCbeta 2 downregulation plays an important role in M1-M2 macrophage differentiation, whereas PI-PLCbeta3 activity is essential for promoting macrophage survival, especially in atherosclerotic plaques. Isoform PI-PLCbeta3 deficiency is also linked to the development of myeloproliferative neoplasm | Homo sapiens |
physiological function | isoform PI-PLCgamma plays a specific key role in cell migration and invasion, therefore contributing to carcinogenesis. Isoform PI-PLCzeta is specifically connected with the molecular activation of oocytes following fertilization. PI-PLCbeta isozymes participate in the differentiation and activation of immune cells that control both the innate and adaptive immune systems. Isoform PI-PLCdelta1 is required for the maintenance of homeostasis in skin and metabolic tissues, while PI-PLCdelta3 specifically regulates microvilli formation in enterocytes and the radial migration of neurons in the cerebral cortex of the developing brain | Homo sapiens |