Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.11 extracted from

  • Henry, J.; Guillotte, A.; Luberto, C.; Del Poeta, M.
    Characterization of inositol phospho-sphingolipid-phospholipase C 1 (Isc1) in Cryptococcus neoformans reveals unique biochemical features (2011), FEBS Lett., 585, 635-640.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Cloned(Commentary)

Cloned (Comment) Organism
expression of sc1 in Saccharomyces cerevisiae DELTAisc1 mutant Cryptococcus neoformans

Protein Variants

Protein Variants Comment Organism
D114A catalytically inactive Isc1 mutant Cryptococcus neoformans
K119A catalytically inactive Isc1 mutant Cryptococcus neoformans
additional information Isc1, site-directed mutagenesis of the P-loop-like domain Cryptococcus neoformans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cryptococcus neoformans Isc1 only exerts IPC-PLC activity ?
-
 ?
additional information Cryptococcus neoformans H99 Isc1 only exerts IPC-PLC activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
 serotype C
-
Cryptococcus neoformans
-
 var. gattii serotype B
-
Cryptococcus neoformans
-
 var. grubii serotype A
-
Cryptococcus neoformans H99
-
 serotype C
-
Cryptococcus neoformans H99
-
 var. gattii serotype B
-
Cryptococcus neoformans H99
-
 var. grubii serotype A
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Isc1 only exerts IPC-PLC activity Cryptococcus neoformans ?
-
 ?
additional information Isc1 only exerts IPC-PLC activity Cryptococcus neoformans H99 ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol phosphosphingolipid-phospholipase C
-
 Cryptococcus neoformans
IPC-PLC
-
 Cryptococcus neoformans
Isc1
-
 Cryptococcus neoformans

General Information

General Information Comment Organism
physiological function Isc1 regulates the level of complex sphingolipids and certain species of phytoceramide, especially when fungal cells are exposed to acidic stress. Either the enzyme Isc1 P-loop is not involved in the substrate recognition or that it is not sufficient to discriminate between phosphoinositide and sphingomyelin Cryptococcus neoformans