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Literature summary for 3.1.4.11 extracted from

  • Bai, C.; Zhao, L.; Tsai, M.D.; Bruzik, K.S.
    Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus (2010), J. Am. Chem. Soc., 132, 1210-1211.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Streptomyces antibioticus saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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 ?

Organism

Organism UniProt Comment Textmining
Streptomyces antibioticus
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-
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Reaction

Reaction Comment Organism Reaction ID
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol kinetic and catalytic reaction mechanism, overview Streptomyces antibioticus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Streptomyces antibioticus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O saPLC1 employs a unique catalytic mechanism whereby the cleavage of phosphatidylinositol into inositol 1-phosphate occurs via a trans cyclization mechanism involving formation of inositol 1,6-cyclic phosphate as an intermediate Streptomyces antibioticus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
additional information synthesis of a short-chain (dihexanoyl) analogues of phosphatidylinositol, which exist as monomers at the concentrations used for the kinetic measurements, the cleavage proceeds with the release of the cyclic phosphorothioate Streptomyces antibioticus ?
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 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol-specific phospholipase C
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 Streptomyces antibioticus
PLC1
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 Streptomyces antibioticus