Literature summary for 3.1.4.11 extracted from

Chayakulkeeree, M.; Sorrell, T.C.; Siafakas, A.R.; Wilson, C.F.; Pantarat, N.; Gerik, K.J.; Boadle, R.; Djordjevic, J.T.
Role and mechanism of phosphatidylinositol-specific phospholipase C in survival and virulence of Cryptococcus neoformans (2008), Mol. Microbiol., 69, 809-826.

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Protein Variants

Protein Variants	Comment	Organism
additional information	creation of deltaplc1 deletion mutant. Deltaplc1 fails to grow at 37°C and exhibits slightly slower, but similar growth at 25°C and 30°C. PLC1 is essential for high-temperature growth and melanin production. PLC1, but not PLC2, is essential for all of these phenotypes and that the absence of the Plc1 enzyme in deltaplc1 compromises activation of the PKC/MAPK pathway. PLC1 is essential for cell wall integrity	Cryptococcus neoformans var. grubii
additional information	creation of deltaplc2 deletion mutant. PLC2 is not essential for all phenotypes	Cryptococcus neoformans var. grubii

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inactive analogue control (U73343) has no antifungal activity against Cryptococcus neoformans; inactive analogue control (U-73343) has no antifungal activity against Cryptococcus neoformans. Deltaplc1 is hypersusceptible to flucytosine, azoles and amphotericin B, but not to caspofungin	Cryptococcus neoformans var. grubii
U-73122	PLC inhibitor, inhibits growth of Cryptococcus neoformans; PLC inhibitor, inhibits growth of Cryptococcus neoformans	Cryptococcus neoformans var. grubii

Organism

Organism	UniProt	Comment	Textmining
Cryptococcus neoformans var. grubii	B4XX94	-	-
Cryptococcus neoformans var. grubii	B4XX95	-	-

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol-specific phospholipase C	-	Cryptococcus neoformans var. grubii
PI-PLC	-	Cryptococcus neoformans var. grubii
PLC1	-	Cryptococcus neoformans var. grubii
PLC2	-	Cryptococcus neoformans var. grubii

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Release 2023.1 (January 2023)