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Literature summary for 3.1.4.11 extracted from

  • Singal, T.; Dhalla, N.S.; Tappia, P.S.
    Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes (2009), Mol. Cell. Biochem., 327, 229-239.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist; increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist Rattus norvegicus
U-73122
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
Western blot analysis Rattus norvegicus
135000
-
Western blot analysis Rattus norvegicus
150000
-
Western blot analysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P10686
-
-
Rattus norvegicus P10687
-
-
Rattus norvegicus P10688
-
-
Rattus norvegicus Q99JE6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
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Synonyms

Synonyms Comment Organism
phospholipase C
-
Rattus norvegicus
PLC beta1
-
Rattus norvegicus
PLC beta3
-
Rattus norvegicus
PLC delta1
-
Rattus norvegicus
PLC gamma1
-
Rattus norvegicus