Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | recruitment of PLC-gamma1 to nephrin activated PLC-gamma1, as detected by phosphorylation of PLC-gamma1 Tyr-783 and increase in inositol 1,4,5-trisphosphate level | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | PLC-gamma1 is bound to phosphorylated nephrin Tyr-1204, which induces translocation of PLC-gamma1 from cytoplasm to the CD8/Nephrin cluster on the plasma membrane | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19174 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase C-gamma1 | - |
Homo sapiens |
PLC-gamma1 | phospho-nephrin-binding protein | Homo sapiens |