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Literature summary for 3.1.4.11 extracted from

  • Ochocka, A.M.; Grden, M.; Sakowicz-Burkiewicz, M.; Szutowicz, A.; Pawelczyk, T.
    Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension (2008), Int. J. Biochem. Cell Biol., 40, 2264-2273.
    View publication on PubMed
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
ARGHAP6 a GTPase-activating protein for RhoA. Activates PLC-gamma1 and increases the Vmax of PLC-beta1 and enhances its response to Ca2+ stimulation. ARHGAP6 protein binds to and up-regulates PLC-beta1 both under in vitro and in vivo conditions Homo sapiens
spermine
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RhoA
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0123
-
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Vmax 58.8 nmol/min/ml without ARHGAP6 and with spermine Homo sapiens
0.0197
-
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Vmax 45.4 nmol/min/ml with ARHGAP6 and without spermine Homo sapiens
0.0232
-
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Vmax 52.6 nmol/min/ml with ARHGAP6 and spermine Homo sapiens
0.0391
-
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Vmax 5.0 nmol/min/ml without ARHGAP6 and spermine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51178
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
phospholipase C-delta1
-
 Homo sapiens