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Literature summary for 3.1.4.11 extracted from

  • Panfoli, I.; Burlando, B.; Viarengo, A.
    Effects of heavy metals on phospholipase C in gill and digestive gland of the marine mussel Mytilus galloprovincialis Lam (2000), Comp. Biochem. Physiol. B, 137B, 391-397.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ is effective only after preincubation, suggesting that the effect of the metal may be derived from lipid peroxidation due to Cu2+-induced oxyradical production Mytilus galloprovincialis
Hg2+ inhibits PLC activity when added directly to the reaction mixture. Toxic effect stronger than that of Cu2+ both in vitro and in vivo, especially for the digestive gland Mytilus galloprovincialis
additional information treatment of mussels with sublethal concentrations of Hg2+ or Cu2+ in vivo produces significant PLC inhibition after 1 or 4 days, respectively. A recovery is reached after 7 days of in vivo metal incubation. Data indicate that in mussel gills and digestive gland heavy metals impair PLC activity, thereby affecting IP3-dependent Ca2+ signaling Mytilus galloprovincialis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ induction of cell Ca2+ disorders can play a primary role in the occurrence of heavy metal cytotoxic effects Mytilus galloprovincialis

Organism

Organism UniProt Comment Textmining
Mytilus galloprovincialis
-
Lam
-
Mytilus galloprovincialis Lam
-
Lam
-

Source Tissue

Source Tissue Comment Organism Textmining
digestive gland
-
Mytilus galloprovincialis
-
gill
-
Mytilus galloprovincialis
-
additional information enzyme activity is assayed in tissue homogenates from gills and digestive gland Mytilus galloprovincialis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.011
-
digestive gland Mytilus galloprovincialis
0.019
-
mussel gill Mytilus galloprovincialis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Mytilus galloprovincialis 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Mytilus galloprovincialis Lam 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?