Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | is effective only after preincubation, suggesting that the effect of the metal may be derived from lipid peroxidation due to Cu2+-induced oxyradical production | Mytilus galloprovincialis | |
Hg2+ | inhibits PLC activity when added directly to the reaction mixture. Toxic effect stronger than that of Cu2+ both in vitro and in vivo, especially for the digestive gland | Mytilus galloprovincialis | |
additional information | treatment of mussels with sublethal concentrations of Hg2+ or Cu2+ in vivo produces significant PLC inhibition after 1 or 4 days, respectively. A recovery is reached after 7 days of in vivo metal incubation. Data indicate that in mussel gills and digestive gland heavy metals impair PLC activity, thereby affecting IP3-dependent Ca2+ signaling | Mytilus galloprovincialis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | induction of cell Ca2+ disorders can play a primary role in the occurrence of heavy metal cytotoxic effects | Mytilus galloprovincialis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mytilus galloprovincialis | - |
Lam | - |
Mytilus galloprovincialis Lam | - |
Lam | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
digestive gland | - |
Mytilus galloprovincialis | - |
gill | - |
Mytilus galloprovincialis | - |
additional information | enzyme activity is assayed in tissue homogenates from gills and digestive gland | Mytilus galloprovincialis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.011 | - |
digestive gland | Mytilus galloprovincialis |
0.019 | - |
mussel gill | Mytilus galloprovincialis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mytilus galloprovincialis | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mytilus galloprovincialis Lam | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |