Literature summary for 3.1.4.11 extracted from

Liu, D.; Liang, H.; Chen, C.; Lin, S.; Zhong, W.; Ho, F.; Hou, W.; Lo, J.; Ho, Y.; Lin, P.; Hung, L.; Liang, Y.
Switch activation of PI-PLC downstream signals in activated macrophages with wortmannin (2007), Biochim. Biophys. Acta, 1773, 869-879.

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Inhibitors

Inhibitors	Comment	Organism	Structure
U73122	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	inhibition of phosphatidylinositol 3-kinase may go through phosphoinositide-specific phospholipase C pathway leading to increase of expression of the inducible nitric oxide synthase, indicating that phosphatidylinositol 3-kinase and phosphoinositide-specific phospholipase C may counteract to regulate the metabolism of phosphatidylinositol (4,5)-bisphosphate depending on cell types or their conditions	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	inhibition of phosphatidylinositol 3-kinase may go through phosphoinositide-specific phospholipase C pathway leading to increase of expression of the inducible nitric oxide synthase, indicating that phosphatidylinositol 3-kinase and phosphoinositide-specific phospholipase C may counteract to regulate the metabolism of phosphatidylinositol (4,5)-bisphosphate depending on cell types or their conditions	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
phosphoinositide-specific phospholipase C	-	Mus musculus
PI-PLC	-	Mus musculus

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Release 2023.1 (January 2023)