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Literature summary for 3.1.4.11 extracted from

  • Sorli, S.C.; Bunney, T.D.; Sugden, P.H.; Paterson, H.F.; Katan, M.
    Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants (2005), Oncogene, 24, 90-100.
    View publication on PubMed
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor epidermal growth factor stimulates PI-PLC activity of both splice variants Homo sapiens
additional information treatment with 5-aza-2'deoxycytidine, an inhibitor of DNA methylation, results in an expression of PLCepsilon1b in tumor cells Homo sapiens
sphingosine 1-phosphate sphingosine-1-phosphate stimulates PI-PLC activity of both splice variants Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS or HEK293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9P212
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
DU-145 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
HEK-293A cell
-
 Homo sapiens
-
HEK-293T cell PLC epsilon1b is only expressed in HEK293T cells Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung PLC epsilon1b is enriched in Homo sapiens
-
additional information PLCepsilon1a can not be detected in SW260 cells and SW480 cells. PLCepsilon can not be detected in LCL cell line, Jurkat cell line, HeLa cell line, A431 cell line, and MCF7 cell line. Splice variants PLC epsilon1a and PLC epsilon1b can not be detected in the peripheral blood leukocyte Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta PLC epsilon1b is enriched in Homo sapiens
-
prostate
-
 Homo sapiens
-
rectum
-
 Homo sapiens
-
SAOS-2 cell
-
 Homo sapiens
-
skeletal muscle only PLC epsilon1a, splice variant PLC epsilon1b can not be detected Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen PLC epsilon1b is enriched in Homo sapiens
-
testis only PLC epsilon1a, splice variant PLC epsilon1b can not be detected Homo sapiens
-
thymus only PLC epsilon1a, splice variant PLC epsilon1b can not be detected Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinosite-specific phospholipase C
-
 Homo sapiens
phospholipase C epsilon
-
 Homo sapiens
phospholipase Cepsilon
-
 Homo sapiens
PI-PLC
-
 Homo sapiens
PLC epsilon
-
 Homo sapiens
PLC epsilon1a PLC epsilon splice variant Homo sapiens
PLC epsilon1b PLC epsilon splice variant Homo sapiens
PLCepsilon splice variants PLCepsilon1a and PLCepsilon1b Homo sapiens