Literature summary for 3.1.4.11 extracted from

Zhang, W.; Neer, E.J.
Reassembly of phospholipase C-b2 from separated domains: analysis of basal and G protein-stimulated activities (2001), J. Biol. Chem., 276, 2503-2508.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Gbetagamma	G protein betagamma subunits, the reconstituted enzymes, like wild-type PLC-beta2, are activated by Gbetagamma	Homo sapiens
additional information	regulated by G protein subunits	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed cDNA constructs encoding PLC-beta2 fragments of different lengths in COS-7 cell. Separate expression of amino- and C-terminal fragments of enzyme, requirements for reconstitution of enzyme activity and activation by Gbetagamma	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q00722	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Homo sapiens	1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?

Synonyms

Synonyms	Comment	Organism
phosphatidylinositol-specific phospholipase C-beta	-	Homo sapiens
phospholipase C-beta2	-	Homo sapiens
PLC-beta2	-	Homo sapiens

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Release 2023.1 (January 2023)