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Literature summary for 3.1.4.11 extracted from
- Action of 2-nonenal and 4-hydroxynonenal on phosphoinositide-specific phospholipase C in undifferentiated and DMSO-differentiated HL-60 cells (2000), Cell Biochem. Funct., 18, 209-214.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-nonenal | at 1-100 nM: activates PL-C in DMSO-differentiated HL-60 cells, at 1-10 nM: activates PL-C in undifferentiated HL-60 cells | Homo sapiens |  |
| 4-hydroxynonenal | at 10-1000 nM, activates PL-C in both undifferentiated and DMSO-differentiated HL-60 cells | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HL-60 cell | promyelocytic cell line, undifferentiated and DMSO-differentiated | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | phosphoinositide-specific | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PL-C | - |
Homo sapiens |
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