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Literature summary for 3.1.4.11 extracted from

  • Rodriguez, R.; Matsuda, M.; Storey, A.; Katan, M.
    Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling (2003), Biochem. J., 374, 269-280.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information membrane targeting of PLCgamma2 constructs containing either PLCdelta1 PH domain or the N-terminal tag of Lyn results in enzyme activation, phosphorylation of PLCgamma2 increases enzyme activity, raft targeting is essential for the B-cell antigen receptor and also for the H2O2 stress-induced 1D-myo-inositol 1,4,5-trisphosphate production in DT40 B-cell line Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant PLCgamma2, expression in DT40 B-cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information constructs of PLCgamma2 containing either PLCdelta1 PH domain or the N-terminal tag of Lyn are targeted to the plasma membrane, recombinant wild-type PLCgamma2 not Homo sapiens
R564A/R672A PLCgamma2 SH2 domain double mutant Homo sapiens
T753F/T759F PLCgamma2 double mutant with reduced phosphorylation level Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PLCgamma2 regulation, role in B-cell signalling ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
PLCgamma2
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PLCgamma2, phosphorylation in response to B-cell antigen receptor stimulation or H2O2 stress, phosphorylation of Tyr-753 and Tyr-759 activates enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structure of PLCgamma2, roles of the different domains Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
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?
additional information PLCgamma2 regulation, role in B-cell signalling Homo sapiens ?
-
?