Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | membrane targeting of PLCgamma2 constructs containing either PLCdelta1 PH domain or the N-terminal tag of Lyn results in enzyme activation, phosphorylation of PLCgamma2 increases enzyme activity, raft targeting is essential for the B-cell antigen receptor and also for the H2O2 stress-induced 1D-myo-inositol 1,4,5-trisphosphate production in DT40 B-cell line | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
wild-type and mutant PLCgamma2, expression in DT40 B-cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | constructs of PLCgamma2 containing either PLCdelta1 PH domain or the N-terminal tag of Lyn are targeted to the plasma membrane, recombinant wild-type PLCgamma2 not | Homo sapiens |
R564A/R672A | PLCgamma2 SH2 domain double mutant | Homo sapiens |
T753F/T759F | PLCgamma2 double mutant with reduced phosphorylation level | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PLCgamma2 regulation, role in B-cell signalling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
PLCgamma2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | PLCgamma2, phosphorylation in response to B-cell antigen receptor stimulation or H2O2 stress, phosphorylation of Tyr-753 and Tyr-759 activates enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | domain structure of PLCgamma2, roles of the different domains | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
additional information | PLCgamma2 regulation, role in B-cell signalling | Homo sapiens | ? | - |
? |