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Literature summary for 3.1.4.11 extracted from
- The triphosphoinositide phosphodiesterase of brain tissue (1964), Biochem. J., 91, 237-243.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| histone | activates | Bos taurus |  |
| protamine | activates | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CuCl2 | 0.1 mM, 53% inhibition | Bos taurus | |
| Cys | 5 mM, 58% inhibition | Bos taurus | |
| diethyl ether | 25% v/v, 22% inhibition | Bos taurus | |
| EDTA | - |
Bos taurus | |
| Hg2+ | 0.1 mM, 90% inhibition | Bos taurus | |
| NEM | 5 mM, 34% inhibition | Bos taurus | |
| PCMB | 0.5 mM, 78% inhibition | Bos taurus | |
| Phenylmercuriacetate | 0.1 mM, 85% inhibition | Bos taurus | |
| reduced glutathione | 6.8 mM, 35% inhibition | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Bos taurus | |
| Mg2+ | activates | Bos taurus | |
| additional information | no absolute requirement | Bos taurus | |
| NaCl | marked activation in presence of lecithin or phosphatidylethanolamine | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylinositol 4,5-bisphosphate + H2O | - |
Bos taurus | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
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Release 2023.1 (January 2023)
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