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Literature summary for 3.1.4.11 extracted from

  • Irvine, R.F.; Letcher, A.J.; Dawson, R.M.C.
    Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms (1984), Biochem. J., 218, 177-185.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.11

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ above 0.1 mM Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, maximal activity at 100 nM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
hepatoma cell rapidly growing hepatoma 3924A Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown Rattus norvegicus ?
-
 ?
phosphatidylinositol 4,5-bisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 5.5
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
4.5 7.5 pH 4.5: about 25% of maximal activity, pH 7.5: about 55% of maximal activity, hydrolysis of phosphatidylinositol 4,5-diphosphate Rattus norvegicus