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Literature summary for 3.1.4.1 extracted from

  • Rechkunova, N.; Lebedeva, N.; Lavrik, O.
    Tyrosyl-DNA phosphodiesterase 1 is a new player in repair of apurinic/apyrimidinic sites (2015), Russ. J. Bioorg. Chem., 41, 474-480 .
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a target for anticancer therapy Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the enzyme hydrolyzes the covalent bond between the tyrosyl residue of topoisomerase 1 and the 3'-phosphate group in DNA. The enzyme is able to initiate the cleavage of internal apurinic/apyrimidinic sites or 3-hydroxy-2-hydroxymethyl tetrahydrofuran in DNA and its subsequent repair ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P38319
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme hydrolyzes the covalent bond between the tyrosyl residue of topoisomerase 1 and the 3'-phosphate group in DNA. The enzyme is able to initiate the cleavage of internal apurinic/apyrimidinic sites or 3-hydroxy-2-hydroxymethyl tetrahydrofuran in DNA and its subsequent repair Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
? x * 68000, calculated from amino acid sequence Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
TDP1
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Saccharomyces cerevisiae
tyrosyl-DNA phosphodiesterase 1
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Saccharomyces cerevisiae