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Literature summary for 3.1.4.1 extracted from

  • Cuya, S.M.; Comeaux, E.Q.; Wanzeck, K.; Yoon, K.J.; van Waardenburg, R.C.
    Dysregulated human tyrosyl-DNA phosphodiesterase I acts as cellular toxin (2016), Oncotarget, 7, 86660-86674 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
H263A the mutant displays reduced in vitro catalytic activity compared to the wild type enzyme Homo sapiens
H493N the mutant displays reduced in vitro catalytic activity compared to the wild type enzyme Homo sapiens
H493R the mutant displays reduced in vitro catalytic activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphohistidyl-linked tyrosyl-DNA phosphodiesterase I-DNA complex + H2O Homo sapiens tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-histidyl bond formed between tyrosyl-DNA phosphodiesterase I and DNA ?
-
 ?
3'-phosphotyrosyl-linked topoisomerase I-DNA complex + H2O Homo sapiens tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-tyrosyl bond formed between DNA topoisomerase I and DNA ?
-
 ?
5'-phosphotyrosyl-linked topoisomerase II-DNA complex + H2O Homo sapiens tyrosyl-DNA phosphodiesterase I hydrolyzes the 5'phospho-tyrosyl bond formed between DNA topoisomerase II and DNA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NUW8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphohistidyl-linked tyrosyl-DNA phosphodiesterase I-DNA complex + H2O tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-histidyl bond formed between tyrosyl-DNA phosphodiesterase I and DNA Homo sapiens ?
-
 ?
3'-phosphotyrosyl-linked topoisomerase I-DNA complex + H2O tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-tyrosyl bond formed between DNA topoisomerase I and DNA Homo sapiens ?
-
 ?
5'-phosphotyrosyl-linked topoisomerase II-DNA complex + H2O tyrosyl-DNA phosphodiesterase I hydrolyzes the 5'phospho-tyrosyl bond formed between DNA topoisomerase II and DNA Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
TDP1
-
 Homo sapiens
tyrosyl-DNA phosphodiesterase I
-
 Homo sapiens