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Literature summary for 3.1.4.1 extracted from

  • Guo, D.; Dexheimer, T.S.; Pommier, Y.; Nash, H.A.
    Neuroprotection and repair of 3-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1) (2014), Proc. Natl. Acad. Sci. USA, 111, 15816-15820.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene gkt, DNA and amino acid sequence determination and analysis Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information homozygous PiggyBac insertion, c03958, disrupts the 5'-UTR of gene gkt resulting in mutant flies that are defective in hydrolyzing 3'-DNA-tyrosyl residues. The phenotype iss rescued by neuronal expression of the enzyme TDP1 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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gene glaikit or gkt
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Synonyms

Synonyms Comment Organism
TDP1
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Drosophila melanogaster
tyrosyl-DNA phosphodiesterase 1
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Drosophila melanogaster

General Information

General Information Comment Organism
evolution the enzyme is phylogenetically conserved Drosophila melanogaster
malfunction the c03958 insertion gene gkt disruption mutant of TDP1 is generally healthy and fertile, but females exhibit reduced lifespan and diminished climbing ability. Insertion mutant c03958 larvae are exposed to bleomycin, an agent that produces oxidative DNA damage, or topoisomerase I-targeted drugs (camptothecin and a noncamptothecin indenoisoquinoline derivative, LMP-776), survivors display rough eye patches, which are rescued by neuronal expression of wild-type enzyme TDP1, overview Drosophila melanogaster
physiological function the enzyme is critical for neuroprotection, normal longevity, and repair of damaged DNA through the removal of blocking lesions at the 3'-ends of DNA or RNA Drosophila melanogaster