Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male | - |
Rattus norvegicus Sprague-Dawley | - |
male | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | arteries from hypertensive rats, vascular PDE1A, PDE1B, PDE1C, and PDE5 isoforms | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PDE 1A | - |
Rattus norvegicus |
phosphodiesterase 1A | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | angiotensin II upregulates phosphodiesterase 1A expression | up |
General Information | Comment | Organism |
---|---|---|
malfunction | phosphodiesterase-1 inhibition decreases vascular contraction in arteries from angiotensin II hypertensive, but not control, rats | Rattus norvegicus |
physiological function | phosphodiesterase 1 plays a role in decreased cGMP level contributing to increased contraction in arteries from hypertensive rats. Ang II augments PDE1 activation, decreasing the bioavailability of cyclic guanosine 3',5'-monophosphate, and contributing to increased vascular contractility, effects of different PDF isozymes, overview | Rattus norvegicus |