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Literature summary for 3.1.4.1 extracted from

  • Lebedeva, N.A.; Rechkunova, N.I.; Lavrik, O.I.
    AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1 (2011), FEBS Lett., 585, 683-686.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Tdp1 is purified to homogeneity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Tdp1 activity on DNA substrate with 3'-dRP moiety in the single strand break. The 15-mer with 3'-dRP is generated by incubating 10 nM AP-DNA with EndoIII, site cleavage activity of tyrosyl-DNA phosphodiesterase 1, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TDP1
-
Homo sapiens
tyrosyl-DNA phosphodiesterase 1
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

General Information

General Information Comment Organism
additional information Tdp1 is known to interact stably with BER proteins: DNA polymerase beta, XRCC1, PARP1 and DNA ligase III Homo sapiens
physiological function role of Tdp1 in the new APE-independent base excision repair pathway in mammals Homo sapiens