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Literature summary for 3.1.4.1 extracted from

  • Perego, P.; Cossa, G.; Tinelli, S.; Corna, E.; Carenini, N.; Gatti, L.; De Cesare, M.; Ciusani, E.; Zunino, F.; Luison, E.; Canevari, S.; Zaffaroni, N.; Beretta, G.L.
    Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition (2011), Biochem. Pharmacol., 83, 27-36.
    View publication on PubMed
Search for more literature for 3.1.4.1

Cloned(Commentary)

Cloned (Comment) Organism
TDP1 overexpression in U2-OS cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knocking down TDP1 in cells expressing a dominant negative form of PARP1 and co-silencing of TDP1 and the checkpoint control gene RAD17, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
IGROV-1 cell
-
 Homo sapiens
-
ovary cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
TDP1
-
 Homo sapiens
tyrosyl-DNA phosphodiesterase 1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism TDP1 knockdown does not produce a change in sensitivity to camptothecin, whereas co-silencing of other pathways cooperating with TDP1 in cell response to topoisomerase I poisons indicates that XRCC1 and BRCA1 are major regulators of sensitivity Homo sapiens
additional information knockdown of the enzyme TDP1 in U2-OS cells does not increase sensitivity to gimatecan Homo sapiens
physiological function tyrosyl-DNA phosphodiesterase 1 plays a unique function as it catalyzes the repair of topoisomerase I-mediated DNA damage. TDP1 alone can account for mild levels of camptothecin resistance, repair of topoisomerase I-mediated DNA damage likely occurs through redundant pathways mainly implicating BRCA1 and XRCC1, but not RAD17 and PARP1 Homo sapiens