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Literature summary for 3.1.4.1 extracted from

  • Cai, Y.; Miller, C.L.; Nagel, D.J.; Jeon, K.I.; Lim, S.; Gao, P.; Knight, P.A.; Yan, C.
    Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells (2011), Arterioscler. Thromb. Vasc. Biol., 31, 616-623.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
IC86340 a PDE1 inhibitor, significantly reduces collagen I in human saphenous vein explants undergoing spontaneous remodeling via ex vivo culture, and acts synergistically with bicarbonate, in the absence of bicarbonate of IC86340, itself has no effect on collagen I protein. PDE1C but not PDE1A is the major isoform responsible for mediating the effects of IC86340. Lysosome inhibitors,. i.e. 2',4'-dichlorobenzamil, a nonselective CNG channel blocker, and the more specific CNG channel blocker, L-cisdiltiazem, block IC86340-mediated collagen I reduction, overview Rattus norvegicus
additional information bicarbonate acts synergistically with inhibitor IC86340 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 isozymes PDE1C and PDE1A
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Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle
-
 Rattus norvegicus
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vascular smooth muscle cell
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
cyclic nucleotide phosphodiesterase 1
-
 Rattus norvegicus
PDE1
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function role and underlying mechanism of cyclic nucleotide phosphodiesterase 1, PDE1, in regulating collagen I in synthetic vascular smooth muscle cells, overview Rattus norvegicus