Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a possible target for drug design in treatment of calcium pyrophosphate dehydrate deposition disease. PC-1 interferes with insulin receptor signaling, a link between mutations in PC-1 and insulin resistance. PC-1 inhibitors may therefore also have use in treating diabetic patients | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dofetilide | - |
Homo sapiens | |
N-(2-[1-[2-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]piperidin-4-yl]ethyl)sulfuric diamide | - |
Homo sapiens | |
N-(2-[1-[6-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]piperidin-4-yl]ethyl)sulfuric diamide | - |
Homo sapiens | |
N-[2-(1-[6,7-dimethoxy-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4-yl]piperidin-4-yl)ethyl]sulfuric diamide | - |
Homo sapiens | |
N-[2-[1-(2-ethyl-6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | - |
Homo sapiens | |
N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | enzyme binding, structure modelling, overview | Homo sapiens | |
N-[2-[1-(6-chloroquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | - |
Homo sapiens | |
N-[2-[1-(7-chloroquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | - |
Homo sapiens | |
N-[2-[1-(7-methoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | PC-1 is a class II transmembrane glycoprotein | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Homo sapiens | - |
AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | PC-1 is a class II transmembrane glycoprotein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | high expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Homo sapiens | AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to a family of enzymes with nucleoside triphosphate pyrophophohydrolase, NTPPPH, activity | Homo sapiens |
NPP-1 | - |
Homo sapiens |
PC-1 | - |
Homo sapiens |
plasma cell membrane protein-1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000035 | - |
- |
Homo sapiens | N-[2-(1-[6,7-dimethoxy-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4-yl]piperidin-4-yl)ethyl]sulfuric diamide | |
0.000036 | - |
- |
Homo sapiens | N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | |
0.000187 | - |
- |
Homo sapiens | N-[2-[1-(7-methoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | |
0.000214 | - |
- |
Homo sapiens | N-[2-[1-(2-ethyl-6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | |
0.0006 | - |
- |
Homo sapiens | N-(2-[1-[6-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]piperidin-4-yl]ethyl)sulfuric diamide | |
0.00245 | - |
- |
Homo sapiens | N-(2-[1-[2-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]piperidin-4-yl]ethyl)sulfuric diamide | |
0.00598 | - |
- |
Homo sapiens | N-[2-[1-(6-chloroquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide | |
0.01 | - |
above | Homo sapiens | N-[2-[1-(7-chloroquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide |
General Information | Comment | Organism |
---|---|---|
malfunction | PC-1 is the major source of the elevated phosphate levels in chondrocytes and fibroblasts of patients with familial calcium pyrophosphate dehydrate deposition disease, CPPD. CPPD crystals may be a hallmark of the pathology of osteoarthritis | Homo sapiens |