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Literature summary for 3.1.4.1 extracted from

  • Goldfine, I.D.; Maddux, B.A.; Youngren, J.F.; Reaven, G.; Accili, D.; Trischitta, V.; Vigneri, R.; Frittitta, L.
    The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities (2008), Endocr. Rev., 29, 62-75.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.1

Activating Compound

Activating Compound Comment Organism Structure
fibroblast growth factor
-
 Homo sapiens
interleukin-1beta
-
 Homo sapiens
additional information insulin levels do not appear to regulate PC-1 levels in humans, PC-1 is overexpressed in patients with insulin resistance Homo sapiens
phorbol myristate acetate
-
 Homo sapiens
protein kinase C activator
-
 Homo sapiens
tissue necrosis factor-alpha
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus, PC-1 overexpression impairs insulin stimulation of insulin receptor activation and downstream signalling, when PC-1 is overexpressed it inhibits insulin-induced insulin receptor beta-subunit tyrosine kinase activity. Homo sapiens

Protein Variants

Protein Variants Comment Organism
K121Q the mutation is closely associated with insulin resistance, type 2 diabetes mellitus, and cardio- and nephrovascular diseases, the product of this polymorphism has a 2-3fold increased binding affinity for the insulin receptor and is more potent than the wild type PC-1 protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information expression of PC-1 is down-regulated during adipocyte maturation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
230000 260000
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PC-1 plays a major role in bone and cartilage metabolism by producing diphosphate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue PC-1 is either overexpressed or overactive in adipose tissue of insulin-resistant individuals both nondiabetic and diabetic Homo sapiens
-
brain
-
 Homo sapiens
-
chondrocyte
-
 Homo sapiens
-
epididymis
-
 Homo sapiens
-
fibroblast dermal fibroblasts, PC-1 is either overexpressed or overactive in fibroblasts of insulin-resistant individuals both nondiabetic and diabetic Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
pancreatic islet
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
salivary gland
-
 Homo sapiens
-
skeletal muscle PC-1 is either overexpressed or overactive in muscle of insulin-resistant individuals both nondiabetic and diabetic Homo sapiens
-
vas deferens
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PC-1 plays a major role in bone and cartilage metabolism by producing diphosphate Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
ectonucleotide pyrophosphatase phosphodiesterase 1
-
 Homo sapiens
ENPP1
-
 Homo sapiens
liver alkaline phosphodiesterase 1
-
 Homo sapiens
liver nucleotide phosphodiesterase
-
 Homo sapiens
PC-1
-
 Homo sapiens
plasma cell antigen 1
-
 Homo sapiens