Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | - |
Rattus norvegicus | |
EDTA | inactivation reversed by Zn2+ | Rattus norvegicus | |
glutathione | - |
Rattus norvegicus | |
guanosine 5'-tetraphosphate | competitive | Rattus norvegicus | |
L-cysteine | - |
Rattus norvegicus | |
Mn2+ | inhibition at higher concentration, 0.1-0.5 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
diadenosine 5',5'''-P1,P4-tetraphosphate | - |
Rattus norvegicus | |
0.011 | - |
diadenosine 5',5'''-P1,P3-triphosphate | - |
Rattus norvegicus | |
0.012 | - |
diguanosine 5',5'''-P1,P4-tetraphosphate | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasmic membrane | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Rattus norvegicus | |
divalent cations | required for activity | Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus | |
Mn2+ | activation with low concentrations, 0.05 mM | Rattus norvegicus | |
Zn2+ | required for activity | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 5'-P1-tetraphospho-P4-5'''-adenosine + H2O | - |
Rattus norvegicus | AMP + ATP | - |
? | |
diadenosine 5',5'''-P1,P3-triphosphate + H2O | - |
Rattus norvegicus | AMP + ADP | - |
? | |
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
dinucleoside tetraphosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | no activity with cAMP | Rattus norvegicus | ? | - |
? | |
additional information | no activity with p-nitrophenylthymidine 3'-phosphate | Rattus norvegicus | ? | - |
? | |
additional information | broad substrate specificity | Rattus norvegicus | ? | - |
? | |
p-nitrophenylthymidine 5'-phosphate + H2O | - |
Rattus norvegicus | 5'-TMP + p-nitrophenol | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | - |
at pH 7.0 less than 10% activity of that at pH 8.5 | Rattus norvegicus |