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Literature summary for 3.1.4.1 extracted from

  • Uriarte, M.; Stalmans, W.; Hickman, S.; Bollen, M.
    Regulation of purified hepatic PC-1 (phosphodiesterase-I/nucleotide pyrophosphatase) by threonine auto(de)phosphorylation and by binding of acidic fibroblast growth factor (1995), Biochem. J., 306, 271-277.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.1

Inhibitors

Inhibitors Comment Organism Structure
ADP PC-1 Rattus norvegicus
AMP PC-1 Rattus norvegicus
ATP PC-1 Rattus norvegicus
dithiothreitol PC-1 Rattus norvegicus
EDTA PC-1 Rattus norvegicus
additional information PC-1, no inhibition by MgCl2 and /or CaCl2 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane PC-1 Rattus norvegicus
-
-
extracellular PC-1, active site of plasma-membrane-associated PC-1 appears to be located extracellularly Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
118000
-
 x * 118000 + x * 128000, PC-1, SDS-PAGE Rattus norvegicus
128000
-
 x * 118000 + x * 128000, PC-1, SDS-PAGE Rattus norvegicus
500000
-
 PC-1, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PC-1, plasma-membrane-associated enzyme with nucleotide pyrophosphatase/phosphodiesterase I activity is probably involved in the clearance of extracellular nucleotides such as ATP and diadenosine polyphosphates ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 PC-1, nucleotide pyrophosphatase/phosphodiesterase I
-

Purification (Commentary)

Purification (Comment) Organism
PC-1, NPP/PDE, nucleotide pyrophosphatase/phosphodiesterase I Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
[nucleotide]n + H2O = [nucleotide]m + nucleotide PC-1, enzymic activities and regulation of PC-1 Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver PC-1, nucleotide pyrophosphatase/phosphodiesterase I Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
411
-
 PC-1, phosphodiesterase I activity, substrate: p-nitrophenylthymidine 5'-phosphate Rattus norvegicus

Storage Stability

Storage Stability Organism
PC-1, -20øC, 150 mM NaCl Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O PC-1 Rattus norvegicus 5'-AMP + diphosphate PC-1 ?
additional information PC-1, plasma-membrane-associated enzyme with nucleotide pyrophosphatase/phosphodiesterase I activity is probably involved in the clearance of extracellular nucleotides such as ATP and diadenosine polyphosphates Rattus norvegicus ?
-
 ?
p-nitrophenylthymidine 5'-phosphate + H2O PC-1 Rattus norvegicus 5'-TMP + p-nitrophenol
-
 ?
UDP-glucose + H2O PC-1 Rattus norvegicus glucose-1-phosphate + 5'-UMP PC-1 ?

Subunits

Subunits Comment Organism
tetramer x * 118000 + x * 128000, PC-1, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
PC-1 PC-1, plasma-cell differentiation antigen-1, a trifunctional enzyme, displaying a phosphodiesterase I /nucleotide pyrophosphatase activity, a protein threonine kinase activity, and a nucleotide-stimulated protein threonine phosphatase activity Rattus norvegicus