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Literature summary for 3.1.4.1 extracted from
- Three diadenosine 5',5'''-P1,P4-tetraphosphate hydrolytic enzymes from Physarum polycephalum with differential effects by calcium: a specific dinucleoside polyphosphate pyrophosphohydrolase, a nucleotide pyrophosphatase, and a phosphodiesterase (1986), Arch. Biochem. Biophys., 248, 502-515.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EGTA | - |
Physarum polycephalum |  |
| Zn2+ | - |
Physarum polycephalum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activation, 50-60 times more stimulatory than Mg2+ or Mn2+ | Physarum polycephalum | |
| Co2+ | no significant effect | Physarum polycephalum | |
| divalent cations | activation | Physarum polycephalum | |
| Mg2+ | slight activation | Physarum polycephalum | |
| Mn2+ | slight activation | Physarum polycephalum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45300 | - |
gel filtration | Physarum polycephalum |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Physarum polycephalum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Physarum polycephalum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasmodium | microplasmodium | Physarum polycephalum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.169 | - |
- |
Physarum polycephalum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine 5'-P1-tetraphospho-P4-5'''-adenosine + H2O | - |
Physarum polycephalum | AMP + ATP | - |
? | |
| adenosine 5'-P1-tetraphospho-P4-5'''-guanosine + H2O | - |
Physarum polycephalum | ? | - |
? | |
| ADP + H2O | - |
Physarum polycephalum | AMP + phosphate | - |
? | |
| ATP + H2O | - |
Physarum polycephalum | 5'-AMP + diphosphate | - |
? | |
| bis(p-nitrophenyl) phosphate + H2O | - |
Physarum polycephalum | ? | - |
? | |
| dinucleoside polyphosphate + H2O | - |
Physarum polycephalum | ? | - |
? | |
| additional information | broad substrate specificity | Physarum polycephalum | ? | - |
? | |
| NADP+ + H2O | - |
Physarum polycephalum | NAD+ + phosphate | - |
? | |
| p-nitrophenyl phenylphosphonate + H2O | - |
Physarum polycephalum | p-nitrophenol + benzenephosphonic acid | - |
? | |
| p-nitrophenylthymidine 5'-phosphate + H2O | - |
Physarum polycephalum | 5'-TMP + p-nitrophenol | - |
? | |
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