Cloned (Comment) | Organism |
---|---|
stable enzyme overexpression in hepatocellular carcinoma Hep3B cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of SND1 in QGY-7703 cells inhibits establishment of xenografts in nude mice | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | high SND1 enzyme expression level | Homo sapiens | - |
hepatocellular carcinoma cell | - |
Homo sapiens | - |
QGY-7703 cell | high SND1 enzyme expression level | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SND1 | - |
Homo sapiens |
staphylococcal nuclease | - |
Homo sapiens |
staphylococcal nuclease domain-containing 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | conditioned medium from Hep3B-SND1 cells stably overexpressing SND1 augmentes, whereas that from QGYSND1si cells stably overexpressing SND1 siRNA significantly inhibits angiogenesis, as analyzed by a chicken chorioallantoic membrane assay and a human umbilical vein endothelial cell differentiation assay | Homo sapiens |
metabolism | inhibition of NF-kappaB blocks enzyme-induced angiogenesis | Homo sapiens |
additional information | staphylococcal nuclease domain-containing 1, SND1, is a multifunctional nuclease containing four staphylococcal nuclease domains and a tudor domain. No potential interaction between enzyme SND1 and p65 subunit of NF-kappa B | Homo sapiens |
physiological function | the enzyme staphylococcal nuclease domain-containing 1, SND1, regulates a variety of cellular functions and promotes an aggressive tumorigenic phenotype in hepatocellular carcinoma cells. Role of SND1 in regulating tumor angiogenesis, a hallmark of cancer, overview. SND1 regulates NF-kappaB and miR-221, two important determinants of hepatocellular carcinoma controlling the aggressive phenotype. The enzyme induces angiogenesis by up-regulating angiogenin and CXCL16. The phosphorylation of IKKalpha and IkappaBalpha upon enzyme overexpression suggests activation of a canonical NF-kappa B signaling pathway by the enzyme | Homo sapiens |