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Literature summary for 3.1.31.1 extracted from

  • Santhekadur, P.K.; Das, S.K.; Gredler, R.; Chen, D.; Srivastava, J.; Robertson, C.; Baldwin, A.S.; Fisher, P.B.; Sarkar, D.
    Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor kappaB and miR-221 (2012), J. Biol. Chem., 287, 13952-13958.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
stable enzyme overexpression in hepatocellular carcinoma Hep3B cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of SND1 in QGY-7703 cells inhibits establishment of xenografts in nude mice Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell high SND1 enzyme expression level Homo sapiens
-
hepatocellular carcinoma cell
-
Homo sapiens
-
QGY-7703 cell high SND1 enzyme expression level Homo sapiens
-

Synonyms

Synonyms Comment Organism
SND1
-
Homo sapiens
staphylococcal nuclease
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Homo sapiens
staphylococcal nuclease domain-containing 1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction conditioned medium from Hep3B-SND1 cells stably overexpressing SND1 augmentes, whereas that from QGYSND1si cells stably overexpressing SND1 siRNA significantly inhibits angiogenesis, as analyzed by a chicken chorioallantoic membrane assay and a human umbilical vein endothelial cell differentiation assay Homo sapiens
metabolism inhibition of NF-kappaB blocks enzyme-induced angiogenesis Homo sapiens
additional information staphylococcal nuclease domain-containing 1, SND1, is a multifunctional nuclease containing four staphylococcal nuclease domains and a tudor domain. No potential interaction between enzyme SND1 and p65 subunit of NF-kappa B Homo sapiens
physiological function the enzyme staphylococcal nuclease domain-containing 1, SND1, regulates a variety of cellular functions and promotes an aggressive tumorigenic phenotype in hepatocellular carcinoma cells. Role of SND1 in regulating tumor angiogenesis, a hallmark of cancer, overview. SND1 regulates NF-kappaB and miR-221, two important determinants of hepatocellular carcinoma controlling the aggressive phenotype. The enzyme induces angiogenesis by up-regulating angiogenin and CXCL16. The phosphorylation of IKKalpha and IkappaBalpha upon enzyme overexpression suggests activation of a canonical NF-kappa B signaling pathway by the enzyme Homo sapiens