Activating Compound | Comment | Organism | Structure |
---|---|---|---|
caspase-3 | cleavage activates inactive enzyme | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
His-tag fusion protein expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Double-stranded RNA | - |
Homo sapiens | |
RNA-DNA heteroduplexes | - |
Homo sapiens | |
single-stranded DNA | - |
Homo sapiens | |
Single-stranded RNA | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dsDNA + H2O | Homo sapiens | primarily responsible for internucleosomal DNA cleavage during the terminal stages of apoptosis, preference for cleaving the internucleosomal linker regions in chromatin | ? | fragments possessing ends with 5-phosphate and 3-hydroxyl groups, exclusively double strand breaks (primarily blunt ends) | ? | |
additional information | Homo sapiens | single-stranded DNA, single-stranded RNA, double-stranded RNA nor RNA-DNA heteroduplexes are not substrates for the enzyme | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein using His-tag | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dsDNA + H2O | primarily responsible for internucleosomal DNA cleavage during the terminal stages of apoptosis, preference for cleaving the internucleosomal linker regions in chromatin | Homo sapiens | ? | fragments possessing ends with 5-phosphate and 3-hydroxyl groups, exclusively double strand breaks (primarily blunt ends) | ? | |
additional information | single-stranded DNA, single-stranded RNA, double-stranded RNA nor RNA-DNA heteroduplexes are not substrates for the enzyme | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | homodimer, crystal structure analysis | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CAD | - |
Homo sapiens |
caspase-activated DNase | - |
Homo sapiens |
DFF | - |
Homo sapiens |
DFF40/CAD endonuclease | - |
Homo sapiens |
DNA fragmentation factor | - |
Homo sapiens |