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Literature summary for 3.1.3.96 extracted from
- HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5-phosphatase (2010), Biochem. J., 431, 237-244.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
| additional information | not inhibited by 5'-UMP at a concentration of 0.3 mM, 1-methylpseudouridine barely inhibits, no inhibition with uridine and adenosine | Homo sapiens | |
| pseudouridine | - |
Homo sapiens | |
| vanadate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00038 | - |
pseudouridine 5'-phosphate | pH 7.1, 30°C | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pseudouridine 5'-phosphate + H2O | Homo sapiens | - |
pseudouridine + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | pseudouridine-5'-phosphatase activity is 1.5-fold higher in erythrocytes from women compared with men | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pseudouridine 5'-phosphate + H2O | - |
Homo sapiens | pseudouridine + phosphate | - |
? | |
| pseudouridine 5'-phosphate + H2O | catalytic efficiency with 3'-AMP, fructose 1,6-bisphosphate, fructose 6-phosphate, 5'-UMP or FMN is less than 1% compared to pseudouridine 5'-phosphate | Homo sapiens | pseudouridine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5'-PsiMPase | - |
Homo sapiens |
| haloacid dehalogenase-like hydrolase domain-containing 1 | - |
Homo sapiens |
| HDHD1 | - |
Homo sapiens |
| pseudouridine 5'-monophosphatase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.6 | - |
pseudouridine 5'-phosphate | pH 7.1, 30°C | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.1 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | X-linked ichthyosis patients harbour a combined deletion of the STS gene (the X-linked ichthyosis gene) and the HDHD1 gene | Homo sapiens |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4184 | - |
pseudouridine 5'-phosphate | pH 7.1, 30°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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