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Literature summary for 3.1.3.95 extracted from

  • Zou, J.; Zhang, C.; Marjanovic, J.; Kisseleva, M.V.; Majerus, P.W.; Wilson, M.P.
    Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8 (2012), Proc. Natl. Acad. Sci. USA, 109, 9539-9544.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q96EF0 isoform MTMR8
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Homo sapiens Q9Y217 isoform MTMR6
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR6 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by over 30fold Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR8 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by 1.4fold Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR6 toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by 2fold Homo sapiens 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O presence of catalytically inactive MTMR9 increases the enzymatic activity of isoform MTMR8 toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by 4fold Homo sapiens 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MTMR6
-
 Homo sapiens
MTMR8
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function complex formation between the active isoform MTMR6 and catalytically inactive MTMR9 increases its catalytic activity and alters its substrate specificity. The MTMR6/MTMR9 complex prefers 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate as substrate. Presence of MTMR9 increases the enzymatic activity of MTMR6 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by over 30fold, and enhances the activity toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by only 2fold. In cells, the MTMR6/R9 complex significantly increases the cellular levels of 1-phosphatidyl-1D-myo-inositol 3-phosphate, the product of 1-phosphatidyl-1D-myo-inositol 3-phosphate dephosphorylation Homo sapiens
physiological function complex formation between the active isoform MTMR6 and catalytically inactive MTMR9 increases its catalytic activity and alters its substrate specificity. The MTMR6/MTMR9 complex prefers 1-phosphatidyl-1D-myo-inositol 3-phosphate as substrate. Presence of MTMR9 increases the enzymatic activity of MTMR8 toward 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate by 1.4fold, and enhances the activity toward 1-phosphatidyl-1D-myo-inositol 3-phosphate by 4fold. In cells, the MTMR8/R9 complex reduces the cellular levels of 1-phosphatidyl-1D-myo-inositol 3-phosphate Homo sapiens