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Literature summary for 3.1.3.95 extracted from

  • Oppelt, A.; Lobert, V.H.; Haglund, K.; Mackey, A.M.; Rameh, L.E.; Liest?l, K.; Schink, K.O.; Pedersen, N.M.; Wenzel, E.M.; Haugsten, E.M.; Brech, A.; Rusten, T.E.; Stenmark, H.; Wesche, J.
    Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration (2013), EMBO Rep., 14, 57-64.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.95

Protein Variants

Protein Variants Comment Organism
C413S mutant without catalytic activity, mutant is unable to rescue the RNAi-knockdown phenotype, indicating that isoform MTMR3 acts enzymatically on phosphoinositides during cell migration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate product stimulates cell migration ?
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MTMR3
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function on depletion of isoform MTMR3 by RNAi, BJ cells are unable to migrate into the wound and show a significant decrease in velocity of about 60% and a decrease in persistence. While 80% of control cells present actin fibres perpendicular to the wound, only 52% of the cells show this on MTMR3 depletion Homo sapiens