Literature summary for 3.1.3.95 extracted from

Walker, D.M.; Urbe, S.; Dove, S.K.; Tenza, D.; Raposo, G.; Clague, M.J.
Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity (2001), Curr. Biol., 11, 1600-1605.

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Cloned(Commentary)

Cloned (Comment)	Organism
heterologously expressed in Saccharomyces cerevisiae	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C413S	catalytically inactive mutant. Overexpression of a catalytically dead MTMR3 (C413S) in mammalian cells induces a striking formation of vacuolar compartments that enclose membranous structures that are highly concentrated in mutant proteins	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13615	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O	the enzyme also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase)	Homo sapiens	1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
MTMR	-	Homo sapiens
MTMR3	-	Homo sapiens
myotubularin-related protein 3	-	Homo sapiens
PtdIns-3,5-P2 3-Ptase	-	Homo sapiens

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Release 2023.1 (January 2023)