Literature summary for 3.1.3.95 extracted from

Schaletzky, J.; Dove, S.K.; Short, B.; Lorenzo, O.; Clague, M.J.; Barr, F.A.
Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases (2003), Curr. Biol., 13, 504-509.

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Activating Compound

Activating Compound	Comment	Organism	Structure
1-phosphatidyl-1D-myo-inositol 5-phosphate	reaction product, acts as a specific allosteric activator of myotubularin MTM1, and myotubularin-related proteins MTMR3 and MTMR6	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y217	isoform MTMR6	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O	-	Homo sapiens	1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate	product causes myotubularin MTM1 to form a heptameric ring that is 12.5 nm in diameter, and it is a specific allosteric activator of myotubularin MTM1, and myotubularin-related proteins MTMR3 and MTMR6	?
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O	-	Homo sapiens	1-phosphatidyl-1D-myo-inositol + phosphate	-	?
additional information	isoform MTMR6 shows similar activity with substrates 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate and 1-phosphatidyl-1D-myo-inositol 3-phosphate	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MTMR6	-	Homo sapiens
myotubularin-related protein 6	-	Homo sapiens

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Release 2023.1 (January 2023)