Literature summary for 3.1.3.9 extracted from

Chen, S.; Pan, C.; Nandigama, K.; Mansfield, B.C.; Ambudkar, S.V.; Chou, J.Y.
The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic (2008), FASEB J., 22, 2206-2213.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-1 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
H176A	mutant is devoid of D-glucose 6-phosphate hydrolase activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35575	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.335	-	enzyme from microsomes, at 25°C	Homo sapiens
0.5473	-	enzyme from octylglucoside-solubilized extract, at 25°C	Homo sapiens
1.065	-	enzyme from proteoliposomes dialyzed against MOPS buffer, at 25°C	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate + H2O	G6Pase facilitates microsomal D-glucose 6-phosphate uptake by D-glucose 6-phosphate transporter	Homo sapiens	D-glucose + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
G6Pase-alpha	-	Homo sapiens
glucose-6-phosphatase-alpha	-	Homo sapiens

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Release 2023.1 (January 2023)