Literature summary for 3.1.3.9 extracted from

Yang, J.; Danke, N.A.; Berger, D.; Reichstetter, S.; Reijonen, H.; Greenbaum, C.; Pihoker, C.; James, E.A.; Kwok, W.W.
Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects (2006), J. Immunol., 176, 2781-2789.

Search for more literature for 3.1.3.9

Application

Application	Comment	Organism
medicine	IGRP is a member of the glucose-6-phosphatase family of proteins and the major autoantigen for autoimmune type 1 diabetes. DR0301-restricted IGRP-specific T cells present in 100% of healthy subjects and type 1 diabetes subjects. DR0401-restricted IGRP-specific T cells present in ca. 80% of the subjects. Cross-reactivity between IGRP and G6Pase-alpha epitopes for DR0401-restricted T cells	Homo sapiens
medicine	islet-specific glucose-6-phosphatase catalytic subunit-related protein is recognized as a major autoantigen for autoimmune type 1 diabetes. More than 80% of subjects with either DRB10401 or DRB10301 haplotype have islet-specific glucose-6-phosphatase catalytic subunit-related protein-specific CD4+ T cell responses for at least one islet-specific glucose-6-phosphatase catalytic subunit-related protein epitope. Islet-specific glucose-6-phosphatase catalytic subunit-related protein-specific T cells from both healthy and type 1 diabetes groups produce both gamma-interferon and interleukin-10	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Homo sapiens	-	type 1 diabetes individuals and individuals with a DR0301 or DR0401 haplotype, which are disease susceptible	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	IGRP13-25 and IGRP226-238 are DR0301-restricted epitopes, whereas IGRP23-35 and IGRP247-259 are DR0401-restricted epitopes	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
IGRP	-	Homo sapiens
islet-specific glucose-6-phosphatase catalytic subunit-related protein	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)