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Literature summary for 3.1.3.9 extracted from

  • Ghosh, A.; Cheung, Y.Y.; Mansfield, B.C.; Chou, J.Y.
    Brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production (2005), J. Biol. Chem., 280, 11114-11119.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning into an andoviral vector of nontagged or FLAG-tagged beta-subunit, expression in COS-1 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
vanadate
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O Mus musculus the brain functional glucose-6-phosphatase complex is capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose D-glucose + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
two enzyme forms with different acid sensitivity and tissue location
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary Mus musculus
-
brain contains a functional glucose-6-phosphatase complex capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose Mus musculus
-
heart
-
Mus musculus
-
intestine
-
Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
additional information expression of the enzyme and of glucose 6-phosphate transporter, overview, two enzyme forms: an acid-sensitive Glc-6-Pase-alpha in liver, kidney and intestine, and an acid-insensitive Glc-6-Pase-beta in astrocytes, overview Mus musculus
-
skeletal muscle
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mus musculus
0.011
-
brain Mus musculus
0.272
-
liver Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
Mus musculus D-glucose + phosphate
-
?
D-glucose 6-phosphate + H2O the brain functional glucose-6-phosphatase complex is capable of endogenous glucose production from glucose 6-phosphate, independent of blood glucose Mus musculus D-glucose + phosphate
-
?

Synonyms

Synonyms Comment Organism
Glc-6-P phosphohydrolase
-
Mus musculus
Glc-6-Pase-alpha
-
Mus musculus
Glc-6-Pase-beta
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
two enzyme forms: an acid-sensitive Glc-6-Pase-alpha in liver, kidney and intestine, and an acid-insensitive Glc-6-Pase-beta in astroctyes Mus musculus