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Literature summary for 3.1.3.9 extracted from

  • Jang, W.; Gomer, R.H.
    Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum (2005), Eukaryot. Cell, 4, 72-81.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.9

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is positively regulated by a secreted multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Dictyostelium discoideum
2.1
-
 D-glucose 6-phosphate pH 7.5, wild-type enzyme Dictyostelium discoideum
2.1
-
 D-glucose 6-phosphate pH 7.5, coutin mutant enzyme Dictyostelium discoideum
2.4
-
 D-glucose 6-phosphate pH 7.5, smlA mutant enzyme Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Dictyostelium discoideum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O Dictyostelium discoideum the enzyme is the key enzyme of the gluconeogenesis pathway, and is positively regulated by a extracellular multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively, while the glucokinase activity is inhibited by CF, regulation overview D-glucose + phosphate
-
 ?
additional information Dictyostelium discoideum cells of Dictyostelium discoideum form groups of about 20000 cells. The group size is regulated in part by a negative feedback pathway mediated by a secreted multipolypeptide complex called counting factor. It appears that part of the counting factor signal transduction pathway involves inhibiting the activity of glucose-6-phosphatase, decreasing intracellular glucose levels and affecting the levels of other metabolites, to regulate group size ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-
Dictyostelium discoideum
-
 wild-type strain AX4 and several mutant strains
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 metabolic activity in different strains, overview Dictyostelium discoideum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
 Dictyostelium discoideum D-glucose + phosphate
-
 ?
D-glucose 6-phosphate + H2O the enzyme is the key enzyme of the gluconeogenesis pathway, and is positively regulated by a extracellular multipolypeptide complex called counting factor, CF, or the CF component coutin, respectively, while the glucokinase activity is inhibited by CF, regulation overview Dictyostelium discoideum D-glucose + phosphate
-
 ?
additional information cells of Dictyostelium discoideum form groups of about 20000 cells. The group size is regulated in part by a negative feedback pathway mediated by a secreted multipolypeptide complex called counting factor. It appears that part of the counting factor signal transduction pathway involves inhibiting the activity of glucose-6-phosphatase, decreasing intracellular glucose levels and affecting the levels of other metabolites, to regulate group size Dictyostelium discoideum ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Dictyostelium discoideum