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Literature summary for 3.1.3.9 extracted from
- Identification and characterisation of a new human glucose-6-phosphatase isoform (2003), FEBS Lett., 551, 159-164.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enzyme isoform of brain: G6PC3 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.3 | - |
D-glucose 6-phosphate | pH 6.5, in disrupted vesicles | Rattus norvegicus |  |
| 0.5 | - |
D-glucose 6-phosphate | pH 5.5, in disrupted vesicles | Rattus norvegicus | |
| 1 | - |
D-glucose 6-phosphate | pH 5.5, in disrupted vesicles | Homo sapiens | |
| 1.3 | - |
D-glucose 6-phosphate | pH 6.5, in not disrupted vesicles | Rattus norvegicus | |
| 2 | - |
D-glucose 6-phosphate | pH 6.5, in disrupted vesicles | Homo sapiens | |
| 4.1 | - |
D-glucose 6-phosphate | pH 5.5, in not disrupted vesicles | Homo sapiens | |
| 4.3 | - |
D-glucose 6-phosphate | pH 6.5, in not disrupted vesicles | Homo sapiens | |
| 5.1 | - |
D-glucose 6-phosphate | pH 5.5, in not disrupted vesicles | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38730 | - |
calculation from sequence of cDNA | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BUM1 | - |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | expression of G6PC3 isoform | Homo sapiens | - |
| heart | expression of G6PC3 isoform | Homo sapiens | - |
| kidney | expression of G6PC1 and G6PC3 isoforms | Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | expression of G6PC1 isoform | Homo sapiens | - |
| placenta | expression of G6PC3 isoform | Homo sapiens | - |
| skeletal muscle | expression of G6PC3 isoform | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-Deoxy-D-glucose 6-phosphate + H2O | a better substrate in disrupted vesicles at pH 5.5 and pH 6.5 | Homo sapiens | 2-Deoxy-D-glucose + phosphate | - |
? | |
| 2-Deoxy-D-glucose 6-phosphate + H2O | only in disrupted vesicles | Rattus norvegicus | 2-Deoxy-D-glucose + phosphate | - |
? | |
| D-glucose 6-phosphate + H2O | - |
Homo sapiens | D-glucose + phosphate | - |
? | |
| D-glucose 6-phosphate + H2O | best substrate in disrupted and not disrupted vesicles at pH 5.5 and pH 6.5 | Rattus norvegicus | D-glucose + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Rattus norvegicus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | best substrate in disrupted and not disrupted vesicles at pH 5.5 and pH 6.5 | Homo sapiens | p-nitrophenol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | structure comparison of G6PC1 and G6PC3 isoforms | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
in disruptes vesicles | Homo sapiens |
| 6.5 | - |
in disruptes vesicles | Rattus norvegicus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | - |
- |
8.5 |
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Release 2023.1 (January 2023)
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