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Literature summary for 3.1.3.9 extracted from

  • Foster, J.D.; Nordlie, R.C.
    The biochemistry and molecular biology of the glucose-6-phosphatase system (2002), Exp. Biol. Med., 227, 601-608.
    View publication on PubMed
Search for more literature for 3.1.3.9

Application

Application Comment Organism
medicine the enzyme catalytic unit is a therapeutic target for the treatment of type 2 diabetes, and the putative D-glucose 6-phosphate transporter component of the system has become a therapeutic target as well Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
enzyme catalytic subunit and D-glucose 6-phosphate transporter component Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
membrane
-
 Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O Homo sapiens enzyme system is required in hepatic D-glucose phosphorylation D-glucose + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
D-glucose 6-phosphate + H2O = D-glucose + phosphate two proposed concepts of structure-function relationships for enzyme, According to the substrate transport-catalytic unit concept, enzyme is a multicomponent system consisting of a fairly non-specific catalytic unit with its active site located on the lumental side of endoplasmic reticulum, and at least three transmembrane-spanning translocases that confer specificity to this system by allowing selective substrates/products access to, or egress from, the sequestered catalytic unit. According to the combined conformational flexibility-substrate transport concept, enzyme is a multifunctional enzyme embedded within the endoplasic reticulum membrane that possess both catalytic and substrate/product transport activities. Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
 Homo sapiens D-glucose + phosphate
-
 ?
D-glucose 6-phosphate + H2O enzyme system is required in hepatic D-glucose phosphorylation Homo sapiens D-glucose + phosphate
-
 ?

Subunits

Subunits Comment Organism
More enzyme is multicomponent system, a 36000 Da enzyme catalytic subunit and a 46000 Da D-glucose 6-phosphate transporter component Homo sapiens