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Literature summary for 3.1.3.9 extracted from

  • Madsen, P.; Jakobsen, P.; Westergaard, N.
    N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors (2001), Bioorg. Med. Chem. Lett., 11, 2165-2167.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibitors of liver enzyme involved in either glycogenolysis or glyconeogenesis ara potential targets for development of new drugs as alternatives to the existing treatments of type 2 diabetes Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
3,4-dichlorobenzaldehyde dibenzylhydrazone
-
Sus scrofa
3-methoxybenzaldehyde dibenzylhydrazone
-
Sus scrofa
4-chlorobenzaldehyde dibenzylhydrazone
-
Sus scrofa
4-hydroxybenzaldehyde dibenzylhydrazone
-
Sus scrofa
4-methoxybenzaldehyde dibenzylhydrazone
-
Sus scrofa
5-chlorotetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
5-ethyltetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
benzaldehyde dibenzylhydrazone
-
Sus scrofa
isonicotinaldehyde dibenzylhydrazone
-
Sus scrofa
additional information a series of N,N-dibenzyl-NĀ’-benzylidnenhydrazine represent a novel class of potent competivitve D-glucose-6-phosphatase catalytic inhibitors using disrupted microsomes Sus scrofa
nicotinaldehyde dibenzylhydrazone
-
Sus scrofa
pyridine-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
tetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
tetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose 6-phosphate + H2O Sus scrofa enzyme catalyses the final step in both glycogenolysis and glyconeogenesis D-glucose + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose 6-phosphate + H2O
-
Sus scrofa D-glucose + phosphate
-
?
D-glucose 6-phosphate + H2O enzyme catalyses the final step in both glycogenolysis and glyconeogenesis Sus scrofa D-glucose + phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Sus scrofa
0.00011
-
5-chlorotetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
0.00014
-
4-methoxybenzaldehyde dibenzylhydrazone
-
Sus scrofa
0.00015
-
4-chlorobenzaldehyde dibenzylhydrazone
-
Sus scrofa
0.00045
-
3-methoxybenzaldehyde dibenzylhydrazone
-
Sus scrofa
0.000704
-
tetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
0.00096
-
benzaldehyde dibenzylhydrazone
-
Sus scrofa
0.00096
-
tetrahydrothiophene-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
0.00128
-
3,4-dichlorobenzaldehyde dibenzylhydrazone
-
Sus scrofa
0.00154
-
4-hydroxybenzaldehyde dibenzylhydrazone
-
Sus scrofa
0.0064
-
pyridine-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
0.011
-
isonicotinaldehyde dibenzylhydrazone
-
Sus scrofa
0.021
-
5-ethyltetrahydrofuran-2-carbaldehyde dibenzylhydrazone
-
Sus scrofa
0.237
-
nicotinaldehyde dibenzylhydrazone
-
Sus scrofa